Kaoru is mentioned to have family in both the manga and anime.
In the third manga volume, Kaoru is told by Nanako that Takehiko is going to Germany the next fall and that he intends to take his wife with him. It upsets her deeply and she runs off. Takehiko finds her. Her parents are mentioned. He told her he was at her home and spoke with her parents before he found her there.
During episode 36, Kaoru goes missing after an upsetting meeting at a doctor appointment. A day has passed and she is still missing. Nanako finds out from a phone call that Kaoru never arrived for a basketball match. Kaoru's family say they have not seen her since the previous day.
She is missing for that entire day as well, but eventually goes home that night. The next morning Nanako called the Orihara's home, and she was told that had returned the night before. There are no other mentions of them in the anime and they make no appearances.
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